Calvin and the Colonel is an animated cartoon television series in 1961 about Colonel Montgomery J. Klaxon, a shrewd fox and Calvin T. Burnside, a dumb bear. Their lawyer was Oliver Wendell Clutch, who was a weasel. The colonel lived with his wife Maggie Belle and her sister Sue, who did not trust the colonel at all. Colonel Klaxon was in the real estate business, but always tried get-rich-quick schemes with Calvin's unwitting help.

The series was an animated remake of Amos 'n' Andy [or, more or less, "Andy and The Kingfish"] and featured the voices of Freeman Gosden and Charles Correll from the radio series. Using animals avoided the touchy racial issues which had led to the downfall of Amos 'n' Andy.

Because of low ratings, the show was cancelled after two months, but returned two months later to complete the first season contract. For a year afterward reruns were seen on Saturday mornings, and eventually syndicated through the 1960s. It was also adapted as a comic book by Dell Comics, and as such the first of two issues was the final installment in the company's extremely prolific Four Color anthology series.